MiR-181b Expression Levels as Molecular Biomarker for Type 2 Diabetes

Investigating the Molecular miRNAs as Biomarkers of Type 2 Diabetes

Introduction: Biomarkers would significantly improve the early detection of the disease and identification of individuals at risk of emerging complications. Diabetes mellitus is a group of diverse and complex metabolic disorders. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus are associated with distinct alterations in the profile of MicroRNAs (miRNAs) in the blood, which are som...

Association of MiR-146a Expression and Type 2 Diabetes Mellitus: A Meta-Analysis

Although deregulation of miR-146a has been reported in type 2 diabetes repeatedly, the direction of deregulation events (up or down) remained to be inconsistent in literatures.  Therefore, in this study, we performed a meta-analysis on the possible association between miR-146a expression levels and type 2 diabetes. A systematic literature searching of PubMed, ISI Web of Science and Google ...

miR-181b as a potential molecular target for anticancer therapy of gastric neoplasms.

OBJECTIVE MicroRNAs (miRNAs) play important roles in carcinogenesis. The aim of the present study was to explore the effects of miR-181b on gastric cancer. METHODS The expression level of miR-181b was quantified by qRT-PCR. MTT, flow cytometry and matrigel invasion assays were used to test proliferation, apoptosis and invasion of miR-181b stable transfected gastric cancer cells. RESULTS miR...

Multiple Biomarker Prediction of Type 2 Diabetes

T ype 2 diabetes is predictable and preventable. Obesity, familial diabetes, and higher-than-normal blood glucose levels are well-known risk factors for development of type 2 diabetes by middle age; recent prediction models have incorporated these with other readily measurable features of metabolic syndrome (elevated blood pressure, low HDL cholesterol, and elevated triglycerides) to generate v...

Identification of circulating miR - 101 , miR - 375 and miR - 802 as 2 biomarkers for type 2 diabetes 3 4 Running title : Circulating miRNA in diabetes

Association of miR-146a rs2910164 and miR-27a rs895819 polymorphisms with type 2 diabetes susceptibility: A Meta-Analysis

Background and Aim: Several investigations have evaluated the association of miR-146a rs2910164 and miR-27a rs895819 single-nucleotide polymorphisms with susceptibility to type 2 diabetes (T2D). However, the findings are conflicting and inconclusive. Therefore, this meta-analysis performed to investigate the association between these polymorphisms and T2D risk. Methods: Studies were identifie...